|
T9050 |
AG-270
|
|
Others
,
Methionine Adenosyltransferase (MAT)
|
|
AG-270 is an allosteric and orally active inhibitor of MAT2A. |
|
T9705 |
TL-895
|
|
BTK
|
|
TL-895 is an ATP-competitive, and highly selective irreversible inhibitor of Bruton’s Tyrosine Kinase(BTK). TL-895 showed good potency with an IC50 of 1.5 nM and a Ki of 11.9 nM. |
|
T12695 |
RBN-2397
|
|
PARP
|
|
RBN-2397 is a potent, selective and orally active accross species NAD+ competitive PARP7 inhibitor with IC50 less than 3 nM. |
|
T8327 |
ONO-7475
|
|
Trk receptor
,
TAM Receptor
|
|
ONO-7475 is an inhibitor with high specificity for anexelekto and MER tyrosine kinase |
|
T28475 |
Pyrazoloacridine
|
PD-115934,NSC 366140,NSC-366140,PD 115,934,PD 115934 |
Apoptosis
,
Topoisomerase
|
|
Pyrazoloacridine (PD 115934) is a nucleic acid binding agent that inhibits the activity of topo I and II with an IC50 of 1.25 μM in K562 cells. Pyrazoloacridine shows anti-cancer activity. |
|
T6079 |
NVP-ADW742
|
ADW742,ADW,GSK 552602A |
Apoptosis
,
IGF-1R
|
|
NVP-ADW742 (ADW) is an IGF-1R inhibitor with IC50 of 0.17 μM, >16-fold more potent against IGF-1R than InsR; little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl and c-Kit. |
|
T2134 |
Dorzolamide hydrochloride
|
MK507 hydrochloride,L671152 hydrochloride,MK-507 (L-671152) HCl,Dorzolamide HCl |
Carbonic Anhydrase
|
|
Dorzolamide hydrochloride (MK507 hydrochloride) is the hydrochloride salt form of dorzolamide, an inhibitor of carbonic anhydrase, a zinc-containing enzyme that catalyzes the rapid conversion of carbon dioxide and water ... |
|
T2669 |
Berzosertib
|
VX-970,VE-822 |
ATM/ATR
|
|
Berzosertib (VE-822) has been used in trials studying the treatment of Ovarian Neoplasms, Ovarian Serous Tumor, Adult Solid Neoplasm, Advanced Solid Tumor, and Advanced Solid Neoplasm, among others. |
|
T2357 |
GSK1059615
|
GSK 1059615,GSK-1059615 |
Apoptosis
,
PI3K
,
mTOR
|
|
GSK1059615 has been used in trials studying the treatment of Lymphoma, Solid Tumours, Endometrial Cancer, Solid Tumor Cancer, and Metastatic Breast Cancer. |
|
T17159 |
Treosulfan
|
NSC 39069,Treosulphan |
DNA Alkylator/Crosslinker
,
DNA Alkylation
|
|
Treosulfan (Treosulphan) is a bifunctional alkylating agent. It also has activity in ovarian cancer and other solid tumor types. |
|
T3709 |
XMD8-87
|
ACK1-B19 |
Tyrosinase
,
PPAR
|
|
XMD8-87 (ACK1-B19) is a TNK2 inhibitor with activity in the inhibition of TNK2 phosphorylation. XMD8-87 and XMD16-5 potently inhibit phosphorylation of TNK2 truncation mutations found in solid tumor types. |
|
T1962 |
ASP3026
|
ASP 3026 |
Apoptosis
,
ALK
|
|
ASP3026 has been used in trials studying the treatment of Solid Tumor, B-Cell Lymphoma, Advanced Malignancies, Positive for Anaplastic Lymphoma Kinase, and Positive for Proto-Oncogene Tyrosine-Protein Kinase ROS. |
|
T77367 |
Urelumab
|
BMS-663513,BMS-66513 |
Others
|
|
Urelumab(BMS-66513) is a humanized IgG4 monoclonal antibody, often used as a CD137 agonist.Urelumab has potential antitumor activity, potentiating tumor cell killing by T-cells and natural killer cells, and enhancing the... |
|
T77688 |
Dipotassium tetrachloroplatinate
|
Potassium tetrachloroplatinate |
Others
|
|
Dipotassium tetrachloroplatinate (Potassium tetrachloroplatinate) exhibits antitumor activity in solid tumor lines and can be used in the treatment of oncological diseases. Dipotassium tetrachloroplatinate also acts as a... |
|
T68455 |
AP23846
|
AP-23846 |
Src
|
|
AP23846 is a novel and potent Src family kinase inhibitor that reduces vascular endothelial growth factor and interleukin-8 expression and abrogates downstream angiogenic processes in human solid tumor cell lines. |
|
T1890 |
Pracinostat
|
SB939 |
Apoptosis
,
HDAC
|
|
Pracinostat (SB939) is a novel HDAC inhibitor with improved in vivo properties compared to other HDAC inhibitors currently in Clinicalal trials, allowing oral dosing. Data demonstrate that Pracinostat is a potent and eff... |
|
T9430 |
Venadaparib
|
NOV140101,IDX-1197 |
PARP
|
|
Venadaparib (NOV140101) (IDX-1197) is a potent, selective and orally active PARP inhibitor with IC50s of 1.4 nM and 1.0 nM for PARP1 and PARP2, respectively. Venadaparib is insensitive to PARP-5. Venadaparib prevents the... |
|
T6157 |
Devimistat
|
CPI-613,CPI613,CPI 613,6,8-Bis(benzylthio)octanoic acid |
Apoptosis
,
Dehydrogenase
,
Mitochondrial Metabolism
|
|
Devimistat (6,8-Bis(benzylthio)octanoic acid) , a lipoate analog, inhibits mitochondrial enzymes pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase, disrupts tumor cell mitochondrial metabolism. It has potent... |
|
T83978 |
Safingol hydrochloride
|
SPC 100270 hydrochloride,L-threo-dihydrosphingosine hydrochloride |
PI3K
,
PKC
|
|
Safingol hydrochloride (L-threo-dihydrosphingosine hydrochloride) is a specific inhibitor of protein kinase C. It induces autophagy in solid tumor cells and cancer cell death by inhibiting the PKC and PI3-kinase pathways... |
|
T6883 |
Samotolisib
|
GTPL8918,LY3023414 |
DNA-PK
,
PI3K
,
mTOR
,
Autophagy
|
|
Samotolisib (LY3023414) is an oral ATP competitive inhibitor of the class I PI3K isoforms, DNA-PK, and mTOR. Samotolisib (LY3023414) has been used in trials studying the treatment of Neoplasm, Solid Tumor, COLON CANCER, ... |
|
T5058 |
Pamiparib
|
BGB-290 |
PARP
|
|
Pamiparib (BGB-290) is an orally active, potent, highly selective PARP inhibitor(IC50 of 0.9 nM and 0.5 nM for PARP1 and PARP2, respectively). It has potent PARP trapping, and capability to penetrate the brain, and can b... |
|
T76787 |
Conatumumab
|
TRAIL-R2 mAb,AMG 655 |
TNF
|
|
Conatumumab (AMG 655) is a monoclonal agonist antibody targeting human death receptor 5 (DR5, TRAILR2) at Kd 1 nM for long DR5 and Kd 0.8 nM for short DR5. Conatumumab induces apoptosis in a variety of tumor types throug... |
|
T76873 |
Nidanilimab
|
CAN04 |
IL Receptor
|
|
Nidanilimab (CAN04) is a fully humanized IL1RAP monoclonal antibody with a Kd value of 1.10 pM. Nidanilimab has antitumor activity, cutting off the IL1α and IL1β signaling pathways and inducing the immune system to destr... |
|
T9972 |
Divarasib
|
GDC-6036 |
Ras
|
|
Divarasib (GDC-6036) (GDC-6036) is an investigational, oral, high-potency and selective KRAS G12C inhibitor with an IC50 of < 0.01 μM. Divarasib irreversibly locks KRAS G12C oncoprotein in an inactive state and inhibi... |
|
T17731L |
CL2A-SN-38 DCA 1279680-68-0(free base)
|
|
Others
|
|
CL2A-SN-38 is a drug-linker conjugate composed of a potent a DNA Topoisomerase I inhibitor SN-38 and a linker CL2A to make antibody drug conjugate (ADC).. CL2A-SN-38 is composed of a potent a DNA Topoisomerase I inhibito... |
|
T10551 |
Bithionol sulfoxide
|
|
Others
|
|
Bithionol sulfoxide is a clinically approved antiparasitic drug with the inhibitory against solid tumor growth in several preclinical cancer models. |
|
T36648 |
Tucatinib hemiethanolate
|
|
|
|
Tucatinib (Irbinitinib) hemiethanolate is a potent, orally active and selective HER2 inhibitor with an IC50 of 8 nM.
Tucatinib hemiethanolate has nanomolar activity against purified HER2 enzyme and is approximately 500-f... |
|
T28310 |
PD 114595
|
PD-114595,PD114595 |
|
|
PD 114595 is a Benzothiopyrano-indazole cpd. PD 114595 belongs to a class of DNA complexers, PD 114595 has curative properties against murine solid tumor models. |
|
T39147 |
Venadaparib hydrochloride
|
IDX-1197 hydrochloride |
|
|
Venadaparib hydrochloride (IDX-1197) is a potent and selective PARP inhibitor that exhibits significant anticancer properties. It is particularly effective in solid tumor research. |
|
T77164 |
Pimivalimab
|
|
|
|
Pimivalimab (JTX-4014), a PD-1 inhibitor, is utilized in solid tumor research [1]. |
|
TP2468 |
PNU-145156E (FCE26644)
|
FCE 26644,FCE26644,PNU-145156E,PNU145156E,FCE-26644,PNU 145156E |
|
|
PNU-145156E (FCE26644) a novel angiogenesis inhibitor, has been shown to block circulating angiogenesis promoting growth factor in animal studies and has shown anti-tumor effects in solid tumors in mice. |
|
T68708 |
Denibulin HCl
|
|
|
|
Denibulin (MN-029) is a novel vascular-disrupting agent that reversibly inhibits microtubule assembly, resulting in disruption of the cytoskeleton of tumor vascular endothelial cells. The results of preclinical study dem... |
|
T69813 |
AZD-6126
|
|
|
|
AZD6126, also known as ANG-453, a water-soluble phosphate prodrug of N-acetylcolchinol with potential antiangiogenesis and antineoplastic activities. AZD-6126 is an angiogenesis inhibitor and tubulin inhibitor potentiall... |
|
T81704 |
Naptumomab
|
|
|
|
Naptumomab, a tumor-targeting superantigen (TTS), is a fusion protein that activates the immune system to recognize and eradicate tumor cells. It shows promise in researching refractory solid tumors, including renal cell... |
|
T76255 |
Certepetide
|
|
|
|
Certepetide (CEND-1), also known as iRGD, is a bifunctional cyclic peptide that enhances tumor penetration. By interacting with alphav-integrins through its RGD motif and activating NRP-1, it transforms the solid tumor m... |
|
T61370 |
DNA-PK-IN-6
|
|
|
|
DNA-PK-IN-6, a robust DNA-PK inhibitor, effectively hampers the activity of DNA-PKcs, thereby significantly impairing the DNA repair mechanism in tumors and instigating apoptosis in cells. Additionally, DNA-PK-IN-6 ampli... |
|
T40486 |
Hexa-N-acetylchitohexaose
|
N-Acetylchitohexaose |
Others
|
|
Hexa-N-acetylchitohexaose enhances disease resistance in crops, and can induce an increase in soybean lignification-related and antioxidant enzyme activities.Hexa-N-acetylchitohexaose is a substrate for lysozyme.Hexa-N-a... |
|
T69766 |
Gusacitinib HCl
|
|
|
|
Gusacitinib, also known as ASN-002 and EN-3351, is a potent dual inhibitor of SYK/JAK kinases. ASN002 showed strong antitumor activity in both hematological and solid tumor xenograft models. ASN002 strongly suppressed ... |
|
T79452 |
Tubulin/HDAC-IN-2
|
|
|
|
Tubulin/HDAC-IN-2 (Compound II-19k) is a dual inhibitor targeting Tubulin and HDAC, exhibiting IC50 values of 0.403 μM for HDAC1, 0.591 μM for HDAC2, 3.552 μM for HDAC3, and 0.459 μM for HDAC6. The compound induces G2 ph... |
|
T74542 |
YM458
|
|
Histone Methyltransferase
|
|
YM458, a potent dual inhibitor of EZH2 and BRD4, exhibits IC50 values of 490 nM and 34 nM, respectively. This compound effectively hinders cell proliferation and colony formation, while also inducing cell cycle arrest an... |
|
T70235 |
Cemadotin hydrochloride
|
|
|
|
Cemadotin hydrochloride is the salt from of Cemadotin (free base), also known as, LU103793, a mitosis inhibitor potentially for the treatment of solid tumours. Cemadotin is also a synthetic derivative of Dolastatin 15,... |
|
T69963 |
Birabresib dihydrate
|
|
|
|
Birabresib dihydrate was initially developed by Mitsubishi Tanabe Pharma Corporation, but then was licensed by OncoEthix, privately held biotechnology company. OTX015 is a selective bromodomains: BRD2, BRD3, and BRD4 inh... |
|
T78528 |
ERX-41
|
|
Others
|
|
ERX-41 is an orally active, stereospecific small molecule that targets lysosomal acid lipase A (LIPA). It induces endoplasmic reticulum (ER) stress, leading to cell death independently of its LIPA activity yet reliant on... |
|
T68389 |
LY2457546
|
|
|
|
LY2457546 is a potent and orally bioavailable inhibitor of multiple receptor tyrosine kinases involved in angiogenic and tumorigenic signalling. LY2457546 demonstrates potent activity against targets that include VEGFR2 ... |
|
T80590 |
Cinrebafusp alfa
|
PRS 343 |
EGFR
|
|
Cinrebafusp alfa (PRS 343) is an anticalin-based bispecific drug with high affinity for both CD137/HER2, displaying dissociation constants (Kd) of 0.3 nM to recombinant human HER2 and 5 nM to human monomeric CD137 (4-1BB... |
|
T68401 |
IG-105
|
|
|
|
IG-105 is a potent microtubule inhibitor with potential anticancer activity. IG-105 inhibits microtubule assembly by binding at colchicine pocket. IG-105 shows a potent anticancer activity in vitro and in vivo and has go... |
|
T77052 |
Latikafusp
|
|
|
|
Latikafusp (AMG 256), a bifunctional fusion protein, combines a PD-1-targeting antibody with an IL-21 mutein, facilitating IL-21 pathway stimulation in PD-1+ cells. It aims to enhance and sustain the functionality of cyt... |
|
T64475 |
FMOC-L-THR
|
|
|
|
FMOC-L-THR (AZP-531) is an analogue of unacylated ghrelin designed to improve glycaemic control and reduce weight. The O-glycosidic linkage and the O-acetyl protection in this building block is stable to both piperidine ... |
|
T36424 |
DSPE-PEG(2000)-amine (sodium salt)
|
|
|
|
DSPE-PEG(2000)-amine is a PEGylated derivative of 1,2-distearoyl-sn-glycero-3-PE . It has been used in the synthesis of solid lipid and thermosensitive liposomal nanoparticles for the delivery of anticancer agents.1,2,3D... |
|
T17731 |
CL2A-SN-38
|
|
Others
|
|
CL2A-SN-38 is a drug-linker conjugate consisting of SN-38, a potent DNA topoisomerase I inhibitor, and linker CL2A, for the manufacture of antibody drug conjugates (ADCs). CL2A-SN-38 provides significant and specific ant... |
